Trifluoroacetic acid → HCID 59556660, compound

Participants

Reaction Steps

TFA (2.0 ml, 26.0 mmol) was added dropwise to a stirred mixture of tert-butyl 2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylsulfonamido)acetate (0.121 g, 0.238 mmol), DCM (5.0 ml) under N2. The mixture was stirred at ambient temperature for 3 hrs then concentrated in vacuo. The resulting solid was triturated in ether, filtered and dried to yield 2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylsulfonamido)acetic acid (46 mg, 0.102 mmol) as a white solid. LCMS (Table 1, Method c) Rt=2.14 min, m/z 450.34 (M−H)−

Provenance & Evidence