Hydroxylamine → HCID 58404362, compound

Participants

Reaction Steps

Under an atmosphere of nitrogen, 4-isopropoxy-3-(trifluoromethyl)benzonitrile (6.5 g, 28.4 mmol) and 50% aqueous hyroxylamine (5.21 mL, 85 mmol) in EtOH (20.0 mL) was heated at 60° C. for 18 hr. Solvents removed in vacuo and the residue was azeotroped with MeOH. The residual solid was purified by precipitation from an ethyl acetate/30-600 C pet/ether mixture (1:2) to give (Z)-N′-hydroxy-4-isopropoxy-3-(trifluoromethyl)benzimidamide (2.51 g, 33.8%) LCMS (Table 1, Method b) Rt=1.89 min, m/z 263.13 (M+H)+.

Provenance & Evidence