HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-imidazole-2-carbaldehyde → (RS)-5-Chloro-1-(1H-imidazol-2-ylmethyl)-2-methyl-2,3-dihydro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-imidazole-2-carbaldehyde | HCID 24955 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-chloro-2-methyl-2,3-dihydro-1H-indole | HCID 59556818 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (RS)-5-Chloro-1-(1H-imidazol-2-ylmethyl)-2-methyl-2,3-dihydro-1H-indole | HCID 59556814 | — |
Reaction Steps
Prepared analogously to Example 1, from 5-chloro-2-methyl-2,3-dihydro-1H-indole, imidazole-2-carboxaldehyde, zinc chloride and sodium cyanoborohydride in methanol. MS (ISP): 250.1 ([{37Cl}M+H]+), 248.2 ([{35Cl}M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834044B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-c0ba9ad74fbc4fe3867189831552b0ac |
| Source note | uspto-grants-2010_11 |