HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 59556828, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1H-imidazole-2-carbaldehyde | HCID 24955 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59556828 | HCID 59556828 | — |
Reaction Steps
Analogously to Example 37, the above compound was obtained from 1,2,3,4-tetrahydro-quinolin-7-ol, di-tert-butyldicarbonate and triethylamine in dichloromethane, then treatment with sodium hydroxide in methanol, then treatment with benzyl bromide and sodium hydride in N,N-dimethylformamide, then treatment with trifluoroacetic acid, then treatment with imidazole-2-carboxaldehyde, zinc chloride and sodium cyanoborohydride in methanol. MS (ISP): 320.0 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834044B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-790c1f1e9b8741cabfb2646a6dacc900 |
| Source note | uspto-grants-2010_11 |