Dimethylformamide → HCID 18752856, compound

Participants

Reaction Steps

1.4 ml of dimethylformamide and 6.98 g (52.3 mmol) of N-chlorosuccinimide were added to a tetrahydrofuran solution (140 ml) containing 12.00 g (49.8 mmol) of 5-bromo-7-nitro-1H-indole, followed by stirring at room temperature overnight. An aqueous 10% sodium thiosulfate was added thereto, followed by extracting with ethyl acetate. The organic layer was successively washed with water and brine, dried over magnesium sulfate and concentrated to dryness, to give 14.84 g of the title compound.

Provenance & Evidence