反应详情

6-Ethoxycarbonylamino-1-methylisoquinoline (0.629 g, Production Example 32b) was dissolved in ethanol (20 ml), to which was then added an aqueous 8 N sodium hydroxide solution (6.8 ml), followed by heating under reflux for 1.5 hours. After cooling as it was to room temperature, an aqueous saturated ammonium chloride was added thereto and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (0.311 g, 72%) as pale yellow crystals.

1. temperatureby heating
2. temperatureunder reflux for 1.5 hours
3. temperatureAfter cooling as it
4. customwas to room temperature
5. extractionthe mixture was extracted with ethyl acetate
6. washThe extract was washed with brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was evaporated