Ammonium Chloride → HCID 22674100, compound

Participants

Reaction Conditions

Reaction Steps

1-Chloro-6-ethoxycarbonylaminoisoquinoline (2.27 g, Production Example 41b) was dissolved in dimethyl sulfoxide (45 ml), to which was then added a 28% sodium methoxide solution (8.7 ml), followed by heating under stirring at 110° C. for 1.5 hours. After cooling as it was to room temperature, an aqueous saturated ammonium chloride was added thereto and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (1.75 g, 84%) as a brown oil.

Provenance & Evidence