4-Nitrobenzenesulfonyl chloride → HCID 22674107, compound

Participants

Reaction Steps

The compound synthesized using 6-amino-1-methoxyisoquinoline (Production Example 43b) and 4-nitrobenzenesulfonyl chloride in the same manner as in Synthetic Example 1b was processed in the same manner as in Production Example 170b, to reduce the nitro group thereof. The resulting compound was dissolved in pyridine and methanesulfonyl chloride was added thereto under ice-cooling, followed by stirring for 4 hours as it was. Brine was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. After evaporating the solvent, the residue was purified by silica gel column and the resulting crystals were recrystallized from ethanol, to give the title compound.

Provenance & Evidence