Hydrochloric Acid → HCID 22674170, compound

Participants

Reaction Conditions

Reaction Steps

203 mg (0.96 mmol) of 4-chlorobenzenesulfonyl chloride was added to a pyridine solution (3 ml) containing 200 mg (0.87 mmol) of 7-amino-4-trifluoromethylcumarin and 1 mg of 4-dimethylaminopyridine, followed by stirring at 70° C. for 50 minutes. An aqueous 2 N hydrochloric acid was added thereto, followed by extracting with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated. The resulting residue was crystallized from ethyl acetate-diisopropyl ether, to give 253 mg of the title compound as a pale yellow solid.

Provenance & Evidence