Sodium Hydroxide → HCID 86601161, compound

HRID 1173310Notes

Reaction equation

HRID 1173310 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]([Cl:16])[C:12](Cl)([Cl:14])[Cl:13])[CH:6]=1>CO>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([Cl:16])=[C:12]([Cl:13])[Cl:14])[CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68717205HCID 68717205, compound

Product 1

HCID 86601161HCID 86601161, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a magnetically stirred solution of 0.228 g (5.7 mmol) of sodium hydroxide in 2.0 mL methanol was slowly added a solution of 1.2 g (4.4 mmol) of the product of Step B in 1.0 mL methanol. A white precipitate was deposited and the reaction mixture was stirred for an additional 3 h. At this point the reaction mixture was evaporated in vacuo and the residue was purified on a silica gel flash chromatography column eluted with hexane. Evaporation of the purified fractions afforded the title compound.

Workup

  1. customAt this point the reaction mixture was evaporated in vacuo
  2. customthe residue was purified on a silica gel flash chromatography column
  3. washeluted with hexane
  4. customEvaporation of the purified fractions

Sources & evidence

ORD record
ord-1136a9339124478b8013aa2771128804
Source dataset
uspto-grants-2010_11
Patent number
US07834062B2

Reaction notes

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