Sodium Hydroxide → HCID 86601166, compound

HRID 1173316Notes

Reaction equation

HRID 1173316 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[C:9]([CH:11]([Cl:16])[C:12](Cl)([Cl:14])[Cl:13])[CH:8]=[C:7]([CH:17]([Cl:22])[C:18](Cl)([Cl:20])[Cl:19])[CH:6]=1>CO>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:17]([Cl:22])=[C:18]([Cl:19])[Cl:20])[CH:8]=[C:9]([C:11]([Cl:16])=[C:12]([Cl:13])[Cl:14])[CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86601167HCID 86601167, compound

Product 1

HCID 86601166HCID 86601166, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a magnetically stirred solution of 30 mg (0.73 mmol) of sodium hydroxide in 0.2 mL methanol was slowly added a solution of 0.122 g (0.28 mmol) of the product of Step B in 0.1 mL methanol. A white precipitate was deposited and the reaction mixture was then stirred overnight. The reaction mixture was then evaporated in vacuo and the residue was purified on a silica gel flash chromatography column eluted with hexane. Evaporation of the purified fractions afforded the title compound.

Workup

  1. customThe reaction mixture was then evaporated in vacuo
  2. customthe residue was purified on a silica gel flash chromatography column
  3. washeluted with hexane
  4. customEvaporation of the purified fractions

Sources & evidence

ORD record
ord-0f68a723944a4deaa6eb1bf5e54b96ca
Source dataset
uspto-grants-2010_11
Patent number
US07834062B2

Reaction notes

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