Hydrochloric Acid → HCID 11725142, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 0.30 g (0.71 mmol) of the product from Step C in 20 mL ethanol was added 3 mL conc. hydrochloric acid and the resulting solution was stirred and heated overnight at 75° C. The reaction mixture was then cooled to room temperature, concentrated in vacuo and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The aqueous layer was separated and re-extracted with EtOAc. The organic layers were combined, dried Na2SO4), filtered and evaporated in vacuo to afford the title compound.

Provenance & Evidence