Sodium Hydroxide → HCID 23692980, compound

HRID 1173350Notes

Reaction equation

HRID 1173350 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[C:9]2[O:10][C:11]3[C:20]([CH3:21])=[CH:19][C:18]([C:22]([OH:24])=[O:23])=[CH:17][C:12]=3[S:13](=[O:16])(=[O:15])[CH2:14][C:8]=2[CH:7]=[C:6]([NH:25][CH:26]=[O:27])[CH:5]=1>O.CO>[Na+:2].[Cl:3][C:4]1[C:9]2[O:10][C:11]3[C:20]([CH3:21])=[CH:19][C:18]([C:22]([O-:24])=[O:23])=[CH:17][C:12]=3[S:13](=[O:15])(=[O:16])[CH2:14][C:8]=2[CH:7]=[C:6]([NH:25][CH:26]=[O:27])[CH:5]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 11552671HCID 11552671, compound

Product 1

HCID 23692980HCID 23692980, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A solution of sodium hydroxide (0.0108 g, 0.27 mmol) in water (0.1 mL) was added to the solution of Example 7 (0.104 g, 0.27 mmol) in methanol (5 mL) and stirred at 25° C. for 15 min, the solvent was removed and dried to obtain the title compound. Yield: 0.11 g, (100%); 1H NMR (DMSO-d6, 300 MHz): δ 2.58 (s, 3H, CH3), 5.16 (s, 2H, CH2), 7.69 (d, 1H, Ar), 7.87 (d, 1H, Ar), 7.95 (s, 1H, Ar), 8.11 (s, 1H, Ar), 8.30 (s, 1H, CHO), 10.78 (s, 1H, NH); MS: m/e (ES−) 380 (M-Na); analysis: C16H11ClNNaO6S.2H2O requires C, 43.70; H, 3.44; N, 3.81; Cl, 8.06; S, 7.29. found: C, 42.88; H, 3.19; N, 3.04; Cl, 8.69; S, 7.67%.

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-2450082d388b41ad9d734c73ebc94bdd
Source dataset
uspto-grants-2010_11
Patent number
US07834052B2

Reaction notes

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