Acetaminophen → N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](cyclopropylmethyl)amino]propyl}oxy)phenyl]acetamide

HRID 1173392Notes

Reaction equation

HRID 1173392 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][OH:21])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.[C:22]([NH:25][C:26]1[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1)(=[O:24])[CH3:23]>>[C:10]([C:9]1[CH:12]=[CH:13][C:6]([N:5]([CH2:4][CH:1]2[CH2:2][CH2:3]2)[CH2:18][CH2:19][CH2:20][O:21][C:29]2[CH:30]=[CH:31][C:26]([NH:25][C:22](=[O:24])[CH3:23])=[CH:27][CH:28]=2)=[CH:7][C:8]=1[C:14]([F:16])([F:17])[F:15])#[N:11]

Participants

3

Reactant 2

HCID 1983AcetaminophenHCID 114607194-[(Cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11611731N-[4-({3-[[4-Cyano-3-(trifluoromethyl)phenyl](cyclopropylmethyl)amino]propyl}oxy)phenyl]acetamide

Procedure

Synthesized as described in Example 1C from 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-acetamidophenol: MS (APCI) m/z 432 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-715a2c581f5f41c1b7e5eb31209ffee7
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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