4-tert-Butylphenol → 4-[(Cyclopropylmethyl)(3-{[4-(1,1-dimethylethyl)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173393Notes

Reaction equation

HRID 1173393 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][OH:21])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.[C:22]([C:26]1[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1)([CH3:25])([CH3:24])[CH3:23]>>[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][O:21][C:29]2[CH:30]=[CH:31][C:26]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:27][CH:28]=2)[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:17])[F:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 73934-tert-ButylphenolHCID 114607194-[(Cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 117189444-[(Cyclopropylmethyl)(3-{[4-(1,1-dimethylethyl)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-tert-butylphenol: MS (APCI) m/z 431 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-af496d845bcd471fa92d001e3eba9081
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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