4-Methoxyphenol → 4-[(Cyclopropylmethyl)(3-{[4-(methyloxy)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173394Notes

Reaction equation

HRID 1173394 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][OH:21])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1>>[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][O:21][C:27]2[CH:28]=[CH:29][C:24]([O:23][CH3:22])=[CH:25][CH:26]=2)[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:17])[F:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 114607194-[(Cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 115386724-[(Cyclopropylmethyl)(3-{[4-(methyloxy)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-methoxyphenol: MS (APCI) m/z 405 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-0bd22de086964857991dfaf4ed703c86
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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