4-Fluorophenol → 4-((Cyclopropylmethyl){3-[(4-fluorophenyl)oxy]propyl}amino)-2-(trifluoromethyl)benzonitrile

HRID 1173395Notes

Reaction equation

HRID 1173395 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][OH:21])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.[F:22][C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1>>[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][O:21][C:26]2[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=2)[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:17])[F:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 114607194-[(Cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 115746844-((Cyclopropylmethyl){3-[(4-fluorophenyl)oxy]propyl}amino)-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-fluorophenol: MS (APCI) m/z 393 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-ffdd9237afbe4340b2ba3298ac16b24d
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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