4-tert-Butylphenol → 4-[(3-{[4-(1,1-Dimethylethyl)phenyl]oxy}propyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173400Notes

Reaction equation

HRID 1173400 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=1.[C:23]([C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][CH:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[CH3:24][C:23]([C:27]1[CH:32]=[CH:31][C:30]([O:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:18][C:19]([F:20])([F:21])[F:22])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:15])[F:17])[CH:7]=2)=[CH:29][CH:28]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 73934-tert-ButylphenolHCID 866062484-[(3-Hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 116625424-[(3-{[4-(1,1-Dimethylethyl)phenyl]oxy}propyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C from 4-[(3-hydroxypropyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-tert-butylphenol: MS (ES) m/z 459 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-9ab1b9a86cdb4cedb4646717e0073b0d
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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