4-(4'-Hydroxyphenyl)-2-butanone → 4-[(2-{[4-(3-Oxobutyl)phenyl]oxy}ethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173411Notes

Reaction equation

HRID 1173411 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.O[C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31](=[O:33])[CH3:32])=[CH:25][CH:24]=1>>[O:33]=[C:31]([CH3:32])[CH2:30][CH2:29][C:26]1[CH:27]=[CH:28][C:23]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 216484-(4'-Hydroxyphenyl)-2-butanoneHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 115687774-[(2-{[4-(3-Oxobutyl)phenyl]oxy}ethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 1C using 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-(4-hydroxyphenyl)-2-butanone: MS (APCI) m/z 459 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-8e66913cae24442a956e543a0c92ea19
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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