5-Hydroxyindole → HCID 11683333, compound

HRID 1173412Notes

Reaction equation

HRID 1173412 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.O[C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][CH:27]=[CH:26]2>>[NH:28]1[C:29]2[C:25](=[CH:24][C:23]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]3[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=3)=[CH:31][CH:30]=2)[CH:26]=[CH:27]1

Participants

3

Reactant 2

HCID 160545-HydroxyindoleHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11683333HCID 11683333, compound

Procedure

Synthesized as described in Example 1C using 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 5-hydroxyindole: MS (APCI) m/z 426 (M−1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-623a311a02ed40bba16665b3473a21c1
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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