Trifluoroacetic acid → HCID 86623733, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl [4-({2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]ethyl}oxy)phenyl]carbamate (0.132 g, 0.262 mmol; Example 27B) in CH2Cl2 (5 mL) at rt was added Et3SiH (0.10 mL, 0.66 mmol), followed by TFA (2 mL). The mixture was stirred 40 min and slowly poured into satd NaHCO3. The whole was extracted with EtOAc (×3). Combined organics were washed (water, brine), dried over Na2SO4, filtered and concentrated in vacuo, yielding 0.098 g of the title compound as a colorless gum which was used without further purification: MS (APCI) m/z 404 (M+1).

Provenance & Evidence