4-(Trifluoromethyl)phenol → HCID 11518170, compound

HRID 1173422Notes

Reaction equation

HRID 1173422 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1>>[F:21][C:18]([F:19])([F:20])[CH2:17][N:4]([CH2:3][CH2:2][O:1][C:27]1[CH:28]=[CH:29][C:24]([C:23]([F:32])([F:31])[F:22])=[CH:25][CH:26]=1)[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=1

Participants

3

Reactant 2

HCID 678744-(Trifluoromethyl)phenolHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11518170HCID 11518170, compound

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-(trifluoromethyl)phenol: MS (El) m/z 456 (M+, 4%), 295 ([M-C7H4F3O]+, 9%), 281 (100%).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-97788865d5154569802f215229c56137
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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