1-(4-hydroxyphenyl)pyrrolidin-2-one → HCID 11698495, compound

HRID 1173428Notes

Reaction equation

HRID 1173428 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.O[C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:33][CH2:32][CH2:31][C:30]2=[O:34])=[CH:25][CH:24]=1>>[O:34]=[C:30]1[CH2:31][CH2:32][CH2:33][N:29]1[C:26]1[CH:27]=[CH:28][C:23]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 7855861-(4-hydroxyphenyl)pyrrolidin-2-oneHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11698495HCID 11698495, compound

Procedure

Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 1-(4-hydroxyphenyl)-2-pyrrolidinone (step A above): MS (APCI) m/z 472 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-f3ac7bb9a65740ab83a3266206469dbc
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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