2-Pyridone → HCID 11501972, compound

HRID 1173433Notes

Reaction equation

HRID 1173433 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[NH:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]1=O>COCCOC>[N:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=1

Participants

4

Reactant 2

HCID 88712-PyridoneHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11501972HCID 11501972, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 2-pyridone, using dry DME as reaction solvent: MS (APCI) m/z 390 (M+1).

Workup

  1. customSynthesized
  2. customas reaction solvent

Sources & evidence

ORD record
ord-9fcda44ccd134f5b9bf1cf3b3bd63edd
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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