4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile → HCID 11503468, compound

HRID 1173436Notes

Reaction equation

HRID 1173436 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[CH:25]=[CH:26][C:27](O)=[N:28][CH:29]=1>COCCOC>[F:21][C:18]([F:19])([F:20])[CH2:17][N:4]([CH2:3][CH2:2][O:1][C:27]1[CH:26]=[CH:25][C:24]([C:23]([F:32])([F:31])[F:22])=[CH:29][N:28]=1)[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=1

Participants

4

Reactant 2

HCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrileHCID 178516044HCID 178516044, compound

Product 1

HCID 11503468HCID 11503468, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 5-trifluoromethyl-2-pyridinol, using dry DME as reaction solvent: MS (ESI) m/z 458 (M+1).

Workup

  1. customSynthesized
  2. customas reaction solvent

Sources & evidence

ORD record
ord-ca8238504be94f3aa5c7e44c2ed8be2f
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

Loading…