4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile → HCID 11647067, compound

HRID 1173437Notes

Reaction equation

HRID 1173437 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[CH3:22][C:23]1[CH:24]=[CH:25][C:26](O)=[N:27][CH:28]=1>COCCOC>[CH3:22][C:23]1[CH:24]=[CH:25][C:26]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[N:27][CH:28]=1

Participants

4

Reactant 2

HCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrileHCID 178426911HCID 178426911, compound

Product 1

HCID 11647067HCID 11647067, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 5-methyl-2-pyridinol, using dry DME as reaction solvent: MS (APCI) m/z 404 (M+1).

Workup

  1. customSynthesized
  2. customas reaction solvent

Sources & evidence

ORD record
ord-7ff6f8fc2416428d9627595a11df272a
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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