HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-hydroxypyridine → 4-[{2-[(5-Bromo-2-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-hydroxypyridine | HCID 599528 | — |
| Reactant | 4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 86623731 | — |
| Product | 4-[{2-[(5-Bromo-2-pyridinyl)oxy]ethyl}(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 11568964 | — |
Reaction Steps
Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 5-bromo-2(1H)-pyridinone using dry DME as the reaction solvent: MS (ESI) m/z 468 (M+1, 79Br), 470 (M+1, 81Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834063B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-c1cde77cb9fd4d2b94fa9cfc6e83d161 |
| Source note | uspto-grants-2010_11 |