6-Fluoropyridin-3-ol → HCID 11661436, compound

HRID 1173441Notes

Reaction equation

HRID 1173441 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:22][C:23]1[N:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1>>[F:22][C:23]1[N:28]=[CH:27][C:26]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 27631086-Fluoropyridin-3-olHCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11661436HCID 11661436, compound

Procedure

Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 6-fluoro-3-pyridinol (step A above): MS (ESI) m/z 408 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-7d8705ca00474260b0a1784196d44800
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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