HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile → N-[6-({2-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]ethyl}oxy)-3-pyridinyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 86623731 | — |
| Reactant | HCID 178474274 | HCID 178474274 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-[6-({2-[[4-Cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]ethyl}oxy)-3-pyridinyl]acetamide | HCID 11704976 | — |
Reaction Steps
Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and N-(6-hydroxy-3-pyridinyl)acetamide, using dry DME as the reaction solvent: MS (ESI) m/z 447 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834063B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-957ee8a654934d7dbbb71312e3e05c06 |
| Source note | uspto-grants-2010_11 |