Triphenylphosphine → HCID 86623737, compound

Participants

Reaction Steps

Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 6-({[4-(methyloxy)phenyl]methyl}oxy)-3-pyridinol (step B above) with the following exceptions: PPh3 was used instead of PBu3, and the reaction was started at 0° C., then allowed to proceed at rt: 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=3.3 Hz, 1H), 7.68 (d, J=8.9 Hz, 1H), 7.37 (m, 2H; AA′XX′), 7.18 (d, J=2.7 Hz, 1H), 7.15 (dd, J=8.9, 3.1 Hz, 1H), 7.00 (dd, J=8.9, 2.7 Hz, 1H), 6.90 (m, 2H; AA′XX′), 6.72 (d, J=8.9 Hz, 1H), 5.23 (s, 2H), 4.20 (t, J=5.1 Hz, 2H; overlapping 4.19), 4.19 (q, J=8.6 Hz, 2H; overlapping 4.20), 3.99 (t, J=5.2 Hz, 2H), 3.81 (s, 3H).

Provenance & Evidence