HCID 86623737, compound → HCID 11640042, compound

Participants

Reaction Steps

A mixture of 4-[(2-{[6-({[4-(methyloxy)phenyl]methyl}oxy)-3-pyridinyl]oxy}ethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (0.270 g, 0.51 mmol; step C above) and Pd—C (0.027 g of 10 wt % on activated carbon (dry basis), ca. 50 wt % H2O, ca. 0.013 mmol Pd) was stirred under an atmosphere of H2 for 45 min and filtered through Celite. The filtrate was adsorbed onto a small amount of silica gel and purified by flash chromatography (MeOH/CH2Cl2), affording 0.160 g of the title compound as a colorless solid: MS (ESI) 406 (M+1).

Provenance & Evidence