HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile → 4-[[2-(4-Pyrimidinyloxy)ethyl](2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 86623731 | — |
| Reactant | HCID 178516534 | HCID 178516534 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-[[2-(4-Pyrimidinyloxy)ethyl](2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | HCID 11618034 | — |
Reaction Steps
Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 4(1H)-pyrimidinone, using dry DME as the reaction solvent: MS (ESI) m/z 391 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834063B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-f3e1cbfea78f4138a4bf8fd32e475c2c |
| Source note | uspto-grants-2010_11 |