4-Fluorophenol → HCID 11567381, compound

HRID 1173463Notes

Reaction equation

HRID 1173463 reaction equation
[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][N:4]([CH2:17][CH2:18][OH:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[F:22][C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1>>[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][N:4]([CH2:17][CH2:18][O:19][C:26]1[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=1)[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 68495138HCID 68495138, compound

Product 1

HCID 11567381HCID 11567381, compound

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-fluorophenol: 1H NMR (400 MHz, CDCl3) δ 7.55 (d, J=8.8 Hz, 1H), 7.10 (d, J=2.4 Hz, 1H), 6.99-6.93 (m, 2H, partially overlapping 6.91), 6.91 (dd, J=8.9, 2.3 Hz, 1H), 6.80-6.73 (m, 2H), 4.07 (t, J=5.7 Hz, 2H), 3.92 (t, J=5.7 Hz, 2H), 3.40 (s, 2H), 1.01 (s, 9H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-986f7beaf3fd4588a4a07e9b1b9c3bac
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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