4'-Hydroxyacetophenone → HCID 11711422, compound

HRID 1173464Notes

Reaction equation

[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][N:4]([CH2:17][CH2:18][OH:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[CH3:22][C:23]([C:25]1[CH:26]=[CH:27][C:28](O)=[CH:29][CH:30]=1)=[O:24]>>[C:23]([C:25]1[CH:26]=[CH:27][C:28]([O:19][CH2:18][CH2:17][N:4]([CH2:3][C:2]([CH3:21])([CH3:20])[CH3:1])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=2)=[CH:29][CH:30]=1)(=[O:24])[CH3:22]

Participants

Reactant 2

HCID 74694'-Hydroxyacetophenone

HCID 68495138HCID 68495138, compound

Product 1

HCID 11711422HCID 11711422, compound

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-hydroxyacetophenone: 1H NMR (400 MHz, CDCl3) δ 7.91 (d, J=8.5 Hz, 2H), 7.57 (d, J=8.8 Hz, 1H), 7.11 (app. s, 1H), 6.92 (app. bd, J=8.9 Hz, 1H), 6.86 (d, J=8.5 Hz, 2H), 4.18 (t, J=5.6 Hz, 2H), 3.96 (t, J=5.6 Hz, 2H), 3.41 (s, 2H), 2.55 (s, 3H), 1.02 (s, 9H).

Workup

customSynthesized

Sources & evidence

ORD record: ord-b89779589b304e6bbf0a895ede5a05ce
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834063B2

Reaction notes

Loading…