Phenol → HCID 11653704, compound

HRID 1173465Notes

Reaction equation

HRID 1173465 reaction equation
[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][N:4]([CH2:17][CH2:18][OH:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[C:22]1(O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH3:1][C:2]([CH3:21])([CH3:20])[CH2:3][N:4]([CH2:17][CH2:18][O:19][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 68495138HCID 68495138, compound

Product 1

HCID 11653704HCID 11653704, compound

Procedure

Synthesized as described in Example 1C from 4-[(2,2-dimethylpropyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile and phenol: 1H NMR (400 MHz, CDCl3) δ 7.55 (d, J=9.0 Hz, 1H), 7.31-7.23 (m, 2H), 7.11 (d, J=2.2 Hz, 1H), 6.69 (app. t, J=7.3 Hz, 1H), 6.91 (dd, J=8.9, 2.4 Hz, 1H), 6.83 (d, J=8.2 Hz, 2H), 4.11 (t, J=5.7 Hz, 2H), 3.93 (t, J=5.7 Hz, 2H), 3.40 (s, 2H), 1.01 (s, 9H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-5928a1a112344633b11e6f6710acb025
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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