5-Fluoro-2-hydroxypyridine → 4-((2,2-Dimethylpropyl){2-[(5-fluoro-2-pyridinyl)oxy]ethyl}amino)-2-(trifluoromethyl)benzonitrile

Participants

Reaction Steps

Synthesized as described in Example 27B from 4-[(2,2-dimethylpropyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 61C) and 5-fluoro-2(1H)-pyridinone: 1H NMR (400 MHz, CDCl3) δ 7.97 (d, J=3.0 Hz, 1H), 7.55 (d, J=8.8 Hz, 1H), 7.35 (m, 1H), 7.27 (d, J=2.7 Hz, 1H; partially obscured by solvent), 6.96-(dd, J=9.0, 2.7 Hz, 1H), 6.66 (ddd, J=9.1, 3.6, 0.6 Hz, 1H), 4.41 (t, J=6.7 Hz, 2H), 3.87 (t, J=6.7 Hz, 2H), 3.33 (s, 2H), 1.00 (s, 9H).

Provenance & Evidence