2-Hydroxy-5-(trifluoromethyl)pyridine → HCID 11575915, compound

Participants

Reaction Steps

Synthesized as described in Example 27B from 4-[(2,2-dimethylpropyl)(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 61C) and 5-(trifluoromethyl)-2(1H)-pyridinone, using dry DME as the reaction solvent: 1H NMR (400 MHz, CDCl3) δ 8.43 (m, 1H), 7.79 (app. dd, J=8.8, 2.6 Hz, 1H), 7.56 (d, J=8.9 Hz, 1H), 7.27 (d, J≈2.6 Hz, 1H; partially obscured by solvent), 6.97 (dd, J=9.0, 2.8 Hz, 1H), 6.78 (partially resolved ddd, J=8.7, ˜0.6, ˜0.6 Hz, 1H), 4.52 (t, J=6.6 Hz, 2H), 3.90 (t, J=6.7 Hz, 2H), 3.34 (s, 2H), 1.00 (s, 9H).

Provenance & Evidence