4'-Hydroxyacetophenone → HCID 11561017, compound

HRID 1173475Notes

Reaction equation

[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=1[C:13]([F:16])([F:15])[F:14].[CH3:22][C:23]([C:25]1[CH:26]=[CH:27][C:28](O)=[CH:29][CH:30]=1)=[O:24]>>[C:23]([C:25]1[CH:26]=[CH:27][C:28]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][C:6]=2[C:13]([F:15])([F:16])[F:14])=[CH:29][CH:30]=1)(=[O:24])[CH3:22]

Participants

Reactant 2

HCID 74694'-Hydroxyacetophenone

HCID 86623738HCID 86623738, compound

Product 1

HCID 11561017HCID 11561017, compound

Procedure

Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-3-(trifluoromethyl)benzonitrile and 4-hydroxyacetophenone: MS (APCI) m/z 431 (M+1).

Workup

customSynthesized

Sources & evidence

ORD record: ord-21a82f06ef1342b1bb859ba9b3724a14
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834063B2

Reaction notes

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