Water → HCID 11517731, compound

Participants

Reaction Steps

An ice-cold solution of 4-[[2-(phenylthio)ethyl](2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (0.056 g, 0.138 mmol) in MeOH (6 mL) was treated with a solution of oxone (0.255 g, 0.415 mmol) in water (3 mL) and stirred at rt. After 1.5 h, the mixture was partitioned between EtOAc and water. The organic phase was washed with water and brine, dried (Na2SO4) and concentrated in vacuo. The residue was purified by silica gel chromatography (5-50% EtOAc/hexanes gradient) and the product crystallized from CH2Cl2/hexanes to give the title compound as a white solid (0.057 g, 95% yield): MS (ES) m/z 437 (M+1).

Provenance & Evidence