4-Methoxyphenol → HCID 56557142, compound

HRID 1173488Notes

Reaction equation

HRID 1173488 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22](O)=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([O:1][CH2:2][CH2:3][NH:4][C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:14])([F:15])[F:16])[CH:6]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 55138540HCID 55138540, compound

Product 1

HCID 56557142HCID 56557142, compound

Procedure

Prepared as described in Example 1C from 4-[(2-hydroxyethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-methoxyphenol: 1H NMR (300 MHz, CDCl3) δ 7.58 (d, J=8.6 Hz, 1H), 6.93 (d, J=1.6 Hz, 1H), 6.85 (s, 4H), 6.76 (dd, J=8.7, 1.7 Hz, 1H), 5.66 (bs, 1H), 4.15 (t, J=4.7, 2H), 3.78 (s, 3H), 3.59 (t, J=4.9 Hz, 2H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c081be6161d44020b3a595f7bc0b03e8
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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