tert-Butyl bromoacetate → HCID 11243130, compound

HRID 1173491Notes

Reaction equation

HRID 1173491 reaction equation
[CH2:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1)[CH2:2][CH3:3].Br[CH2:18][C:19]([O:21]C(C)(C)C)=[O:20]>>[C:9]([C:8]1[CH:11]=[CH:12][C:5]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:18][C:19]([OH:21])=[O:20])=[CH:6][C:7]=1[C:13]([F:14])([F:15])[F:16])#[N:10]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 114246984-(Propylamino)-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11243130HCID 11243130, compound

Procedure

Synthesized as described in Example 70B using 4-(propylamino)-2-(trifluoromethyl)benzonitrile and 1,1-dimethylethyl bromoacetate: 1H NMR (400 MHz, CDCl3) δ 7.61 (d, J=8.7 Hz, 1H), 6.87 (d, J=2.6 Hz, 1H), 6.71 (dd, J=8.8, 2.6 Hz, 1H), 4.18 (s, 2H), 3.41 (t, J=7.7 Hz, 2H), 1.68 (m, 2H), 0.98 (t, J=7.5 Hz, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-b3c9796bfdd1400d917a96a51736ecff
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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