1-Phenethylamine, (+)- → N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N2-(cyclopropylmethyl)-N1-[(1R)-1-phenylethyl]glycinamide

HRID 1173503Notes

Reaction equation

HRID 1173503 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH2:10][C:11]([OH:13])=O)=[CH:5][C:4]=1[C:18]([F:21])([F:20])[F:19])#[N:2].[C:22]1([C@H:28]([NH2:30])[CH3:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH2:10][C:11]([NH:30][C@@H:28]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:29])=[O:13])=[CH:5][C:4]=1[C:18]([F:21])([F:20])[F:19])#[N:2]

Participants

3

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 11369986N-[4-Cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)glycine

Product 1

HCID 70831371N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N2-(cyclopropylmethyl)-N1-[(1R)-1-phenylethyl]glycinamide

Procedure

Synthesized as described for Example 91C using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)glycine and (1R)-1-phenylethanamine: MS (APCI) m/z 402 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-ad54e8a3ee8742ec93fb62b5c89cefbb
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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