Aniline → HCID 86623741, compound

HRID 1173504Notes

Reaction equation

HRID 1173504 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([OH:14])=O)[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:17][CH2:18]2)[C@H:10]([C:12]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:14])[CH3:11])=[CH:5][C:4]=1[C:19]([F:21])([F:22])[F:20])#[N:2]

Participants

3

Reactant 2

HCID 6115AnilineHCID 11278376HCID 11278376, compound

Product 1

HCID 86623741HCID 86623741, compound

Procedure

Synthesized as described for Example 91C using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alanine and aniline: 1H NMR (400 MHz, CDCl3) δ 8.20 (s, 1H), 7.51 (d, J=8.9 Hz, 1H), 7.45 (d, J=7.9 Hz, 2H), 7.30 (t, J=7.7 Hz, 2H), 7.16 (d, J=2.4 Hz, 1H), 7.11 (t, J=7.5 Hz, 1H), 6.93 (dd, J=8.9, 2.7 Hz, 1H), 4.47 (q, J=7.0 Hz, 1H), 3.37 (m, 2H), 1.56 (d, J=6.9 Hz, 3H), 1.12 (m, 1H), 0.69 (m, 2H), 0.37 (m, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-c0255da6c8224c4ab56ec7ea682ad431
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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