4-Fluoroaniline → HCID 86623742, compound

HRID 1173505Notes

Reaction equation

HRID 1173505 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([OH:14])=O)[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[F:23][C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][CH:25]=1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([NH:28][C:27]2[CH:29]=[CH:30][C:24]([F:23])=[CH:25][CH:26]=2)=[O:14])[CH3:11])=[CH:5][C:4]=1[C:19]([F:20])([F:21])[F:22])#[N:2]

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 11278376HCID 11278376, compound

Product 1

HCID 86623742HCID 86623742, compound

Procedure

Synthesized as described for Example 91C using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alanine and 4-fluoroaniline: 1H NMR (400 MHz, CDCl3) δ 8.21 (s, 1H), 7.50 (d, J=8.7 Hz, 1H), 7.42 (m, 2H), 7.14 (d, J=2.5 Hz, 1H), 7.00-6.91 (m, 3H), 4.47 (q, J=7.0 Hz, 1H), 3.36 (m, 2H), 1.56 (d, J=7.1 Hz, 3H), 1.10 (m, 1H), 0.69 (m, 2H), 0.35 (m, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-ab1a4b435acb4677ac1f852d9780e4fb
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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