tert-Butyl bromoacetate → HCID 11460776, compound

HRID 1173506Notes

Reaction equation

HRID 1173506 reaction equation
[CH2:1]([NH:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=1)[CH:2]([CH3:4])[CH3:3].Br[CH2:19][C:20]([O:22]C(C)(C)C)=[O:21]>>[C:10]([C:9]1[CH:12]=[CH:13][C:6]([N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH2:19][C:20]([OH:22])=[O:21])=[CH:7][C:8]=1[C:14]([F:15])([F:16])[F:17])#[N:11]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 43138501HCID 43138501, compound

Product 1

HCID 11460776HCID 11460776, compound

Procedure

Synthesized as described in Example 70B using 4-(isobutylamino)-2-(trifluoromethyl)benzonitrile and 1,1-dimethylethyl bromoacetate: 1H NMR (400 MHz, CDCl3) δ 7.59 (d, J=9.0 Hz, 1H), 6.90 (d, J=2.6 Hz, 1H), 6.72 (dd, J=9.0, 2.7 Hz, 1H), 4.19 (s, 2H), 3.26 (d, J=7.5 Hz, 2H), 2.04 (m, 1H), 0.97 (d, J=6.6 Hz,

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-1afbc9c9a8ae4d5f9d006803b9c67a5b
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

Loading…