4-Aminoacetanilide → N1-[4-(Acetylamino)phenyl]-N2-[4-cyano-3-(trifluoromethyl)phenyl]-N2-(2,2,2-trifluoroethyl)glycinamide

HRID 1173511노트

반응식

HRID 1173511 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:10][C:11]([OH:13])=O)=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31](=[O:33])[CH3:32])=[CH:26][CH:25]=1>>[C:31]([NH:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:11](=[O:13])[CH2:10][N:9]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([C:19]([F:20])([F:22])[F:21])[CH:5]=2)[CH2:14][C:15]([F:16])([F:17])[F:18])=[CH:25][CH:26]=1)(=[O:33])[CH3:32]

참가 물질

3

반응물 2

HCID 312304-AminoacetanilideHCID 57633731N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine

생성물 1

HCID 86623745N1-[4-(Acetylamino)phenyl]-N2-[4-cyano-3-(trifluoromethyl)phenyl]-N2-(2,2,2-trifluoroethyl)glycinamide

실험 절차

Synthesized as described for Example 91C using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(2,2,2-trifluoroethyl)glycine and N-(4-aminophenyl)acetamide: MS (APCI) m/z 459 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-7787e26417d648dd850b7b2b4abe6268
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834063B2

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