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HRID 1173669作成日：2026年10月25日

2-Chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile → Rac-2-chloro-4-[(2r,3r)-2-ethyl-3-hydroxy-3,4,4-trimethyl-5-oxopyrrolidin-1-yl]benzonitrile

https://huagongshe.com/reaction/1173669

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrileHCID 59557016—
反応物HCID 178420675HCID 178420675—
生成物Rac-2-chloro-4-[(2r,3r)-2-ethyl-3-hydroxy-3,4,4-trimethyl-5-oxopyrrolidin-1-yl]benzonitrileHCID 67105654—

反応手順

Using 2-chloro-4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (48 mg) and methylmagnesium bromide-THF solution (1.65 mL, 1.0 mol/L), and in the same manner as in Example 2, the title compound was obtained as a colorless solid (yield: 27 mg, 53%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07834051B2
出典データセットuspto-grants-2010_11
ORD IDord-e0171c2ba2a8411ebdca0c2d525ac3e6
出典メモuspto-grants-2010_11