HCID 59556993, compound → HCID 67105635, compound

HRID 1173682Notes

Reaction equation

HRID 1173682 reaction equation
[F:1][C:2]1[C:9]([CH3:10])=[C:8]([N:11]2[CH:15]([CH3:16])[C:14](=[O:17])[C:13]([CH3:19])([CH3:18])[C:12]2=[O:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:21][Mg]Br.C1COCC1>>[F:1][C:2]1[C:9]([CH3:10])=[C:8]([N:11]2[C:12](=[O:20])[C:13]([CH3:19])([CH3:18])[C@:14]([OH:17])([CH3:21])[C@H:15]2[CH3:16])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 59556993HCID 59556993, compoundHCID 178420675HCID 178420675, compound

Product 1

HCID 67105635HCID 67105635, compound

Procedure

Using 2-fluoro-3-methyl-4-(3,3,5-trimethyl-2,4-dioxopyrrolidin-1-yl)benzonitrile (60 mg) and methylmagnesium bromide-THF solution (2.19 mL, 1.0 mol/L), and in the same manner as in Example 2, the title compound was obtained as colorless crystals (yield: 40 mg, 63%).

Sources & evidence

ORD record
ord-83e31a0a895d41f18650d62b4c086c98
Source dataset
uspto-grants-2010_11
Patent number
US07834051B2

Reaction notes

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