Formic Acid → HCID 59203391, compound

Participants

Reaction Steps

Ethyl 2-chloro-3-oxohexanoate (194 mg), DMF (2.4 ml), RuCl[(S,S)-MesDPEN](p-cymene) complex (1 mol %) and triethylamine (5 equivalents) were mixed, and formic acid (5 equivalents) was gradually added thereto. The reaction was carried out at 40° C. for 3 hours. The reaction mixture was analyzed. As a result, the conversion ratio was 97%, and the isomer ratio of (2S,3R):(2S,3S):(2R,3R):(2R,3S) is 94.7:1.3:0:4.0. In the above, “Mes” represents a methylenesulfonyl group.

Provenance & Evidence