4-Methoxycarbonylphenylboronic acid → HCID 59557397, compound

HRID 1173822Notes

Reaction equation

HRID 1173822 reaction equation
Br[C:2]1[CH:23]=[CH:22][C:5]2[S:6][C:7]([CH2:9][CH:10]3[CH2:14][CH2:13][N:12]([CH:15]4[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]4)[C:11]3=[O:21])=[CH:8][C:4]=2[CH:3]=1.[CH3:24][O:25][C:26]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)=[O:27]>>[CH3:24][O:25][C:26](=[O:27])[C:28]1[CH:33]=[CH:32][C:31]([C:2]2[CH:23]=[CH:22][C:5]3[S:6][C:7]([CH2:9][CH:10]4[CH2:14][CH2:13][N:12]([CH:15]5[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]5)[C:11]4=[O:21])=[CH:8][C:4]=3[CH:3]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 11710884HCID 11710884, compound

Product 1

HCID 59557397HCID 59557397, compoundYield 78%

Procedure

Using the procedure to synthesize Example 17 and using reagents 3-(5-bromo-benzo[b]thiophen-2-ylmethyl)-1-cyclohexyl-pyrrolidin-2-one (250 mg, 0.64 mmol) and 4-methoxycarbonylphenylboronic acid (200 mg, 1 mmol) afford the title compound as a white powder (160 mg, 78%): MS (APCI-pos mode) m/z (rel intensity): 342.2 (M+H, 100%).

Workup

  1. customto synthesize Example 17

Sources & evidence

ORD record
ord-529505ca5e09437ca64190794f919029
Source dataset
uspto-grants-2010_11
Patent number
US07834194B2

Reaction notes

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